In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Lesions and the Relation With Risk Factors A Study Using Integrated Backscatter Intravascular Ultrasound

• Sano Keiji

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Kawasaki Masanori

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Okubo Munenori

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Yokoyama Haruko

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Ito Yoko

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Murata Ichijiro

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Kawai Takao

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Tsuchiya Kunihiko

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Nishigaki Kazuhiko

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Takemura Genzou

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Minatoguchi Shinya

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Zhou Xiangrong

  Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Fujita Hiroshi

  Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

• Fujiwara Hisayoshi

  Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

書誌事項

タイトル別名

• A Study Using Integrated Backscatter Intravascular Ultrasound

抄録

Background Autopsy studies have shown atherosclerotic changes in angiographically normal coronary lesions (ANCL), and conventional intravascular ultrasound shows intimal thickening in these lesions, but cannot differentiate the lipid core. Accurate characterization of ANCL is essential to prevent progression to coronary artery disease. Methods and Results ANCL (n=120) were analyzed by integrated backscatter intravascular ultrasound (IB-IVUS) in 30 patients with stable angina pectoris. Of the 120 arterial segments analyzed by IB-IVUS, 78 (65%) showed lipid cores of 0.69±0.35 mm² with fibrous caps of 200±100 μm thick, 44 (37%) had intimal hyperplasia with a thickness of 350±100 μm, and 65 (54%) showed fibrosis in the intimal wall without lipid core with a thickness of 450±150 μm. The diabetes mellitus (DM) group (n=14) had significantly (p<0.05) bigger lipid cores (0.62±0.38 mm²) and thinner intimal hyperplasia (100±100 μm) compared with the non-DM group (0.31±0.33 mm², 150±150 μm, respectively). The hypertension (HT) group (n=23) had significantly more intimal hyperplasia (150±150 μm) compared with the non-HT group (50±100 μm). Hyperlipidemia (n=16) or smoking (n=6) did not significantly affect tissue characteristics. Conclusion IB-IVUS showed various types of plaque in ANCL and the plaque characteristics were affected by DM and HT. The results provide new clinical insight into the early stage of human coronary atherosclerosis. (Circ J 2005; 69: 543 - 549)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 69 (5), 543-549, 2005

  一般社団法人 日本循環器学会

キーワード

• Coronary disease
• Imaging
• Plaque
• Tissue
• Ultrasonics

詳細情報

• CRID: 1390282680081592448
• NII論文ID: 110002696138
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.69.543
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• HANDLE: 20.500.12099/31985
• PubMed: 15849440
• Web Site: https://gifu-u.repo.nii.ac.jp/records/77798
• Web Site: http://www.jstage.jst.go.jp/article/circj/69/5/69_5_543/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006262511
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可