In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Lesions and the Relation With Risk Factors : A Study Using Integrated Backscatter Intravascular Ultrasound

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Author(s)

    • SANO Keiji
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • KAWASAKI Masanori
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • OKUBO Munenori
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • YOKOYAMA Haruko
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • ITO Yoko
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • MURATA Ichijiro
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • KAWAI Takao
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • TSUCHIYA Kunihiko
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • NISHIGAKI Kazuhiko
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • TAKEMURA Genzou
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • MINATOGUCHI Shinya
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • ZHOU Xiangrong
    • Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • FUJITA Hiroshi
    • Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine
    • FUJIWARA Hisayoshi
    • Regeneration & Advanced Medical Science, Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine

Abstract

<b>Background</b> Autopsy studies have shown atherosclerotic changes in angiographically normal coronary lesions (ANCL), and conventional intravascular ultrasound shows intimal thickening in these lesions, but cannot differentiate the lipid core. Accurate characterization of ANCL is essential to prevent progression to coronary artery disease. <b>Methods and Results</b> ANCL (n=120) were analyzed by integrated backscatter intravascular ultrasound (IB-IVUS) in 30 patients with stable angina pectoris. Of the 120 arterial segments analyzed by IB-IVUS, 78 (65%) showed lipid cores of 0.69±0.35 mm<sup>2</sup> with fibrous caps of 200±100 μm thick, 44 (37%) had intimal hyperplasia with a thickness of 350±100 μm, and 65 (54%) showed fibrosis in the intimal wall without lipid core with a thickness of 450±150 μm. The diabetes mellitus (DM) group (n=14) had significantly (p<0.05) bigger lipid cores (0.62±0.38 mm<sup>2</sup>) and thinner intimal hyperplasia (100±100 μm) compared with the non-DM group (0.31±0.33 mm<sup>2</sup>, 150±150 μm, respectively). The hypertension (HT) group (n=23) had significantly more intimal hyperplasia (150±150 μm) compared with the non-HT group (50±100 μm). Hyperlipidemia (n=16) or smoking (n=6) did not significantly affect tissue characteristics. <b>Conclusion</b> IB-IVUS showed various types of plaque in ANCL and the plaque characteristics were affected by DM and HT. The results provide new clinical insight into the early stage of human coronary atherosclerosis. (<i>Circ J</i> 2005; <b>69:</b> 543 - 549)<br>

Journal

  • Circulation Journal

    Circulation Journal 69(5), 543-549, 2005-04-20

    Japanese Circulation Society

References:  24

Cited by:  6

Codes

  • NII Article ID (NAID)
    110002696138
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  IR  J-STAGE 
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