Functional Assessment by Myocardial Performance Index (Tei Index) Correlates With Plasma Brain Natriuretic Peptide Concentration in Patients With Hypertrophic Cardiomyopathy

• Okawa Makoto

  Department of Medicine and Geriatrics, Kochi Medical School

• Kitaoka Hiroaki

  Department of Medicine and Geriatrics, Kochi Medical School

• Matsumura Yoshihisa

  Department of Medicine and Geriatrics, Kochi Medical School

• Kubo Toru

  Department of Medicine and Geriatrics, Kochi Medical School

• Yamasaki Naohito

  Department of Medicine and Geriatrics, Kochi Medical School

• Furuno Takashi

  Department of Medicine and Geriatrics, Kochi Medical School

• Doi Yoshinori

  Department of Medicine and Geriatrics, Kochi Medical School

Abstract

Background Hypertrophic cardiomyopathy (HCM) might exhibit not only diastolic, but also latent systolic dysfunction. Therefore combined assessment of both systolic and diastolic function using myocardial performance index (Tei index) can be useful in HCM. Plasma brain natriuretic peptide (BNP) level is reported to be elevated in HCM, but the mechanism of BNP elevation in HCM remains to be established. Methods and Results The value of Tei index in 45 HCM patients was compared with that of 20 normal control subjects. The HCM patients showed a higher value of Tei index (0.55±0.12 vs 0.36±0.08, p<0.0001) and longer isovolumic relaxation and contraction times than control subjects. The plasma BNP level correlated with Tei index in non-obstructive HCM (n=35, r=0.61, p<0.0001), although the correlation was mild when overall HCM patients were included (r=0.34, p=0.02). The correlation was still significant after adjusting for age, or the extent and severity of left ventricular hypertrophy. Multiple stepwise regression analysis identified mitral E/A ratio (r=0.49, F=13.1) and Tei index (r=0.37, F=7.6) as independent predictors of higher plasma BNP level in non-obstructive HCM. Conclusions Myocardial performance index was abnormal in HCM, reflecting both systolic and diastolic dysfunction in this disorder. Plasma BNP level correlated with functional assessment by Tei index in non-obstructive HCM. (Circ J 2005; 69: 951 - 957)<br>

Journal

• Circulation Journal

  Circulation Journal 69 (8), 951-957, 2005

  The Japanese Circulation Society

Keywords

• Brain natriuretic peptide
• Cardiac function
• Hypertrophic cardiomyopathy
• Tei index

Details

• CRID: 1390282680079740672
• NII Article ID: 110002696207
• NII Book ID: AA11591968
• DOI: 10.1253/circj.69.951
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 16041165
• Web Site: http://www.jstage.jst.go.jp/article/circj/69/8/69_8_951/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006279297
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed