Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats

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  • HIRAO Akira
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • YAMASAKI Masao
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • CHUJO Hitoi
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • KOYANAGI Nami
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • KANOUCHI Hiroaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • YASUDA Shin
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • MATSUO Aya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • NISHIDA Eri
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • RIKIMARU Tatsuya
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • TSUJITA Eiji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • SHIMADA Mitsuo
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • MAEHARA Yoshihiko
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
  • TACHIBANA Hirofumi
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bloscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • YAMADA Koji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

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Abstract

We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH Was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat popula-tion was heavier than the control rat population at the time of PH and 1-d after PH. Con-versely, CLA fed raduced liver weight was significantly lower than control rats at 7-d after PH. This suggests that dietary CLA reduced liver weight gain after PH. Dietary CLA did not affect serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities. How-ever, CLA significantly reduced serum albumin levels at 1-d but not at 7-d after PH. 5-Promo- and 5-iododeoxyuridine incorporation into hepatocytes 1-d post PH was lower in the CLA group. In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition.

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