Effects of Glucosyl Hesperidin on Serum Lipids in Hyperlipidemic Subjects : Preferential Reduction in Elevated Serum Triglyceride Level

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抄録

Although hesperidin lowers serum total cholesterol (TC) or triglyceride (TG) in animal models, its effect in humans remains unclear. Using a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), as a hesperidin source, we examined the efficacy on hyperlipidemic subjects. G-Hesperidin was administered to the subjects at 100 or 500mg/d for 6 wk. The percentage of subjects who had a change in serum cholesterol levels was less than 20%. However, 45-55% of the total subjects showed a reduction in serum TG level. The subjects were classified into normal (TC<230mg/dL, TG<150mg/dL), high-TC (TC>230mg/dL, TG<150mg/dL) and high-TG (TG>150mg/dL) types. While serum cholesterol levels scarcely changed in any phenotype, TG level was significantly reduced by administration in the high-TG type. In this phenotype, serum apolipoprotein (apo) C-II and E levels decreased by the administration, but non-apo B. G-Hesperidin also raised low-density lipoprotein (.LDL)-cholesterollapo B in the high-TG type. These results indicate that Ghesperidin preferentially lowers serum TG in hypertriglyceridemic subjects and that this effect is possibly caused by the facilitation of catabolism of TG-rich lipoproteins and may contribute to the reduction of small dense LDL.

収録刊行物

  • Journal of nutritional science and vitaminology

    Journal of nutritional science and vitaminology 50(3), 211-218, 2004-06-01

    日本ビタミン学会

参考文献:  41件中 1-41件 を表示

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    110002703988
  • NII書誌ID(NCID)
    AA00703822
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03014800
  • NDL 記事登録ID
    7005650
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z53-B484
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
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