Molecular Mechanisms Involved in Determination of Muscle Fibre Mass and Phenotype. Molecular mechanisms involved in the determination of muscle fibre mass and phenotype

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著者

    • Goldspink Geoffrey Goldspink Geoffrey
    • Department of Anatomy and Developmental Biology, Division of Biomedical Sciences, The Royal Free and University College Medical School, University of London

抄録

G. GOLDSPINK, Moiecular Mechanisms invoived in the Determination of Muscle Fibre Mass and Phemthype. Abv. Exerc. Sports Physiol., Vol.5, No.2 pp.27-39, 1999. Skekectal muscle is one of the best exaples of a tissue that can adapt by qualitatively and quantiatively changing gene expression in response to functional demands. The genes include the members of myosin heavy chain (he) family which are involved not only in muscle mass regulation but are the main determinants fo muscle fibre phenotype as they encode us to identify which myosin genes are wxpressed in single fibres during growth and during exercise. This has shown that the main fast fibre types in human are 2x nad 2a and not 2b as in rat muscle. In order to understand the regulation of the indivisual ecnes we have studied their 5' and 3' flanking soquences and used their promter sequences to engincered genes to inject them back into muscle for bene therapy purpose as well as to study regulation. However, in order to after gene expression, mechanical signals have to transduced into chemical signals. Our group have cloned toe cDNA of two splice wariants of the insulin like growth factor(IGF-1) gene that are produced by active muscle. These inclide a liver or endocrine type (L,IGF-a) and another we call mechano growth factor (MGF) that appears to have a local or sutocrine/paracrine function. Although the liver is usually thougt of as source of circulating IGF-1, it has recently been shown that during exercise, skeletal muscle produces much of the circulating IGF-1. Therefore these growth factors appear to be involved in both local repair and maintenance of muscke mass and leads to adaptive remodeling.

G.GOLDSPINK, Molecular Mechanisms Involved in the Determination of Muscle Fibre Mass and Phenotype.Adv.Exerc.Sports Physiol., Vol.5, No.2 pp27-39, 1999. Skeletal muscle is one of the best examples of a tissue that can adapt by qualitatively and quantitatively changing gene expression in response to functional demands. The genes include the members of the myosin heavy chain(hc)family which are involved not only in muscle mass regulation but are the main determinants of muscle fibre phenotype as they encode different molecular motors. Molecular biology methods have enabled us to identify which myosin genes are expressed in single fibres during growth and during exercise. This has shown that the main fast fibre types in human are 2x and 2a and not 2b as in rat muscle. In order to understand the regulation of the individual genes we have studied their 5'and 3'flanking sequences and used their promoter sequences to engineered genes to inject them back into muscle for gene therapy purposes as well as to study regulation. However, in order to alter gene expression, mechanical signals have to be transduced into chemical signals. Our group have cloned the cDNA of two splice variants of the insulin like growth factor(IGF-1)gene that are produced by active muscle. These include a liver or endocrine type(L.IGF-1)and another we call mechano growth factor(MGF)that appears to have a local or autocrine/paracrine function. Although the liver is usually thought of as the source of circulating IGF-1, it has recently been shown that during exercise, skeletal muscle produces much of the circulating IGF-1. Therefore these growth factors appear to be involved in both local repair and maintenance of muscle mass and leads to adaptive remodelling.

収録刊行物

  • Advances in exercise and sports physiology

    Advances in exercise and sports physiology 5(2), 27-39, 1999-05

    Japan Society of Exercise and Sports Physiology

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各種コード

  • NII論文ID(NAID)
    110002705371
  • NII書誌ID(NCID)
    AA11107566
  • 本文言語コード
    ENG
  • 資料種別
    Journal Article
  • ISSN
    13403141
  • NDL 記事登録ID
    9764690
  • NDL 雑誌分類
    ZF21(教育--体育)
  • NDL 請求記号
    Z61-F145
  • データ提供元
    CJP引用  NDL  NII-ELS  IR  NDL-Digital 
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