Studies on Bredinin (II) Effect of Guanine Derivatives on Cytotoxicity and Teratogenicity of Bredinin in Rats

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Bredinin had teratogenic and embryo-lethal actions in mice and rats. These actions were reduced by the administration of guanosine to pregnant rats. In vitro, bredinin inhibited the proliferation of mouse embryo cells at a concentration of more than 10^<-7>M. The inhibitory effect was diminished by the addition of guanosine 5'-monophosphate (GMP) or guanosine to the culture medium. These results suggest that the teratogenic actions of bredinin are induced from a cytotoxic effect which is possibly due to bredinin competition with guanosine in fetal cells.

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