胃癌に対する電撃化学療法後抗癌剤組織内移行に関する検討  [in Japanese] Analysis of Intracellular Influx of Anticancer Drug after Electrical Impulse Chemotherapy for Gastric Cancer  [in Japanese]

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Author(s)

Abstract

We have previously reported the tumoricidal effect of a single high-voltage electrical impulse on a tumor together with an anticancer drug treatment, i.e., electrical impulse chemotherapy. We studied the intracellular influx of anticancer drug in electrical impulse chemotherapy by means of the analysis of the anticancer drug concentration in tumor and normal mucosa. Before resection of the stomach, a single electrical impulse (5KV.,3ms) were applied in 15 patients with advanced gastric cancer 2 hours after the intravenous administration of Cisplatin (35mg/m2). The concentration of Cisplatin was 0.80^+_- 0.16μg/g in tumor, which was significantly higher as compared with the values of 0.60^+_-0.15μg/g in normal mucosa (p<0.05). It is suggested that spike wave electrical impulse chemotherapy induce electroporation of the cell membrane and permit the intracellular influx of a large amount of anticancer drug, exerting a strong cartinostatic effect.

We have previously reported the tumoricidal effect of a single high-voltage electrical impulse on a tumor together with an anticancer drug treatment, i.e., electrical impulse chemotherapy. We studied the intracellular influx of anticancer drug in electrical impulse chemotherapy by means of the analysis of the anticancer drug concentration in tumor and normal mucosa. Before resection of the stomach, a single electrical impulse (5KV.,3ms) were applied in 15 patients with advanced gastric cancer 2 hours after the intravenous administration of Cisplatin (35mg/m2). The concentration of Cisplatin was 0.80^+_- 0.16μg/g in tumor, which was significantly higher as compared with the values of 0.60^+_-0.15μg/g in normal mucosa (p<0.05). It is suggested that spike wave electrical impulse chemotherapy induce electroporation of the cell membrane and permit the intracellular influx of a large amount of anticancer drug, exerting a strong cartinostatic effect.

Journal

  • 山口医学

    山口医学 50(3), 645-650, 2001-06-28

    山口大学医学会

References:  14

Codes

  • NII Article ID (NAID)
    110002774077
  • NII NACSIS-CAT ID (NCID)
    AN00243156
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    05131731
  • Data Source
    CJP  NII-ELS  IR 
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