糖尿病性浮腫性硬化症の一例  [in Japanese] A Case of Scleredema Associated with Diabetes Mellitus  [in Japanese]

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Abstract

A 66-year-old male complained of thickening of the skin at the face, posterior neck and back after a febrile episode. The patient had obesity, elevated levels of HbA1C and urinary C-peptide. The seological tests for collagen diseases were negative. The serum level of vascular endothelial growth factor (VEGF) was elevated. The biopsied skin specimen revealed the thickening of the dermis by the increased proliferation of collagen fibers, thickening of collagen bundles with fenestrations and infiltration of lymphocytes. Scleredema caused by diabestes mellitus and obesity was diagnosed, accompanied with insulin resistance. The patient was initially treated with administration of prednisolone, followed with diet therapy. Scleredema ameliorated partially, however elevated level of VEGF persisted after 6 months of discharge. It is unclear whether elevated level of VEGF may be related to the pathogenesis of the disease or may be an aggravating factor.

A 66-year-old male complained of thickening of the skin at the face, posterior neck and back after a febrile episode. The patient had obesity, elevated levels of HbA1C and urinary C-peptide. The seological tests for collagen diseases were negative. The serum level of vascular endothelial growth factor (VEGF) was elevated. The biopsied skin specimen revealed the thickening of the dermis by the increased proliferation of collagen fibers, thickening of collagen bundles with fenestrations and infiltration of lymphocytes. Scleredema caused by diabestes mellitus and obesity was diagnosed, accompanied with insulin resistance. The patient was initially treated with administration of prednisolone, followed with diet therapy. Scleredema ameliorated partially, however elevated level of VEGF persisted after 6 months of discharge. It is unclear whether elevated level of VEGF may be related to the pathogenesis of the disease or may be an aggravating factor.

Journal

  • 山口医学

    山口医学 52(5), 183-187, 2003-10-31

    山口大学医学会

References:  12

Codes

  • NII Article ID (NAID)
    110002774298
  • NII NACSIS-CAT ID (NCID)
    AN00243156
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    05131731
  • Data Source
    CJP  NII-ELS  IR 
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