マイコトキシンパツリンの生合成 The biosynthesis of the mycotoxin, patulin.

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Patulin is a typical mycotoxin originally isolated from Penicillium patulum as an antibiotic, and the patulin biosynthetic pathway is a classical example of the large group of polyacetate-dervied secondary metabolites known as polyketides. Unexpected metabolites produced by a patulin-deficient mutant revealed a new portion of the pathway. We have investigated the patulin biosynthetic pathway with the aid of several patulin-deficient mutants, pathway enzymology, bioconvesion of metabolites, and immobilized cell techniques. It was found that three mycotoxins (phyllostine, isoepoxydon and ascladiol) and a new lactone (neopatulin) exist on the pathway. Two dehydrogenases among the pathyway enzymes were characterized. Furthemore, in contrast to the accepted assumption, monooxygenase mediated the ring cleavage of an aromatic precursor, gentisaldehyde. Finally, the patulin pathway becomes twice as long as the portion known before 1978,and is one of the best characterized pathways of secondary metabolism. In this monograph, mechanisms of the conversion of phyllostine to neopatulin, and neopatulin to phyllostine, are proposed, and a pathway for the related mycotoxin, penicillic acid, is also discussed.

収録刊行物

  • 醗酵工学会誌

    醗酵工学会誌 61(3), p129-137, 1983-05

    日本生物工学会

各種コード

  • NII論文ID(NAID)
    110002777554
  • NII書誌ID(NCID)
    AN00205237
  • 本文言語コード
    JPN
  • ISSN
    03856151
  • NDL 記事登録ID
    2593536
  • NDL 刊行物分類
    RA11;SC171
  • NDL 雑誌分類
    ZP15(科学技術--化学・化学工業--醗酵・微生物工学)
  • NDL 請求記号
    Z17-395
  • データ提供元
    NDL  NII-ELS  NDL-Digital 
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