Opposite effects of the maternal immune system activated by interleukin-1β vs. PSK and OK432 on 5-azacytidine-induced birth defects
Bibliographic Information
- Other Title
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- Opposite effects of the maternal immune system activated by interleukin 1 ベータ vs PSK and OK432 on 5 azacytidine induced birth defects
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Abstract
<jats:p><jats:bold>ABSTRACT </jats:bold> Effects of stimulation of the maternal immune system on abnormal pregnancy induced with 5‐azacytidine (5ACDR) administration at embryonic day 7.5 (E7.5) were examined in mice treated with recombi‐nant interleukin 1β (IL‐1β) at E6.5 (5ACDR + IL‐1 at E6.5) or E9.5 (5ACDR+IL‐1 at E9.5), OK432 (5ACDR + OK432) at E7.5 or PSK (5ACDR+PSK) at E7.5. Embryos from these dams were examined at E13.5. The frequency of dead and malformed embryos and number of malformations on each embryo increased in the 5ACDR + IL‐1 at E6.5 groups compared with the 5ACDR‐alone group. Adverse pregnancy outcomes in the 5ACDR + OK432 and 5ACDR + PSK groups were less frequent than in the 5ACDR‐alone group. The frequency of exencephaly, facial cleft, eye anomalies (micro‐ or anophthalmos), and micrognathia significantly increased in the 5ACDR + IL‐1 groups, in contrast, that of exencephaly decreased in the 5ACDR + OK432 and 5ACDR + PSK groups compared with the 5ACDR‐alone group. The phagocytes on the exencephalic surface drastically increased in the 5ACDR + IL‐1 groups, and they often appeared to ingest the migrating neuroepithelial cells. Such findings, however, were rarely observed in the 5ACDR‐alone, 5ACDR + OK432 and 5ACDR + PSK groups. Thus, administration of IL‐1β to the abnormal pregnant dams increased the mortality and severity of the malformations in the embryos caused by 5ACDR, whereas PSK or OK432 decreased them. These results suggest that the different modes of activation of the maternal immune system may exert alternative or opposite effects on teratogenic pregnancy.</jats:p>
Journal
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- Congenital anomalies : the official journal of the Japanese Teratology Society
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Congenital anomalies : the official journal of the Japanese Teratology Society 43 (1), 46-56, 2003
Kyoto : Japanese Teratology Society
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Details 詳細情報について
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- CRID
- 1521417755275689344
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- NII Article ID
- 110002785599
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- NII Book ID
- AN10066760
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- ISSN
- 09143505
- 17414520
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- NDL BIB ID
- 6541704
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- Web Site
- http://id.ndl.go.jp/bib/6541704
- https://ndlsearch.ndl.go.jp/books/R000000004-I6541704
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2003.tb01026.x
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2003.tb01026.x
- https://search.jamas.or.jp/link/ui/2003250078
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- Text Lang
- en
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- NDL Source Classification
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- ZS32(科学技術--医学--小児科学・先天異常・奇形)
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- Data Source
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- NDL
- Crossref
- CiNii Articles