Phenotypic differences in the brains and limbs of mutant mice caused by differences of Gli3 gene expression levels

• Ichiro Naruse

• Hiromi Keino

• Yasukazu Yamada

抄録

ABSTRACT  The genetic polydactyly/arhinencephaly mouse, Pdn/Pdn , exhibits severe polydactyly both in the fore‐and hindlimbs, agenesis of the olfactory bulbs, corpus callosum, anterior commissure, and hydrocephalus. A candidate gene for the Pdn mouse has been speculated to be Gli3 , because Pdn has been considered to be an allele of Xt whose responsible gene has been clarified to be Gli3. Recently, it has been cleared that retro‐transposons are inserted into nitron 3, upstream of zinc finger domain, of the Gli3 gene in the Pdn mouse, resulting to the severe suppression of Gli3 gene expression in Pdn/Pdn embryos. Meanwhile, Xt J /Xt J mice exhibit more severe polydactyly than that of Pdn/Pdn. Arhinencephaly and microholoprosencephaly including agenesis of the olfactory bulbs, corpus callosum, anterior commissure, hippocampal commissure, habenular commissure, and posterior commissure, and moreover, the cerebral cortical plates and hippocampus are not formed in the Xt J /Xt J mice. The Xt J /Xt J mouse has a large deletion in Gli3 structural gene and shows null expression. From these corroborations, we speculated that the differences in the Gli3 gene expression levels resulted in the phenotypic differences between the Pdn/Pdn and Xt J /Xt J mice.

収録刊行物

• Congenital anomalies : the official journal of the Japanese Teratology Society

  Congenital anomalies : the official journal of the Japanese Teratology Society 41 (2), 89-94, 2001

  Kyoto : Japanese Teratology Society

キーワード

• Pdn
• Xt
• Gli3
• arhinencephaly
• olfactry bulb
• corps callosum
• Greig cephalopolysyndactyly syndrome
• GCPS

詳細情報

• CRID: 1520573330112831360
• NII論文ID: 110002785797
• NII書誌ID: AN10066760
• ISSN: 09143505
• ISSN: 17414520
• DOI: 10.1111/j.1741-4520.2001.tb00819.x
• NDL書誌ID: 5821811
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5821811
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2001.tb00819.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2001.tb00819.x
• Web Site: https://search.jamas.or.jp/link/ui/2002014755
• 本文言語コード: en
• NDL 雑誌分類:
  • ZS32(科学技術--医学--小児科学・先天異常・奇形)
• データソース種別:
  • NDL
  • Crossref
  • CiNii Articles