Val-Tyrは消化管プロテアーゼ耐性なイワシ由来のACE阻害ペプチドである

• 関 英治

• 筬島 克裕

• 松藤 寛

• 松井 利郎

• 筬島 豊

書誌事項

タイトル別名

• Val-Tyr, an Angiotensin I Converting Enzyme Inhibitor from Sardines that have Resistance to Gastrointestinal Proteases
• Val-Tyr.ワ ショウカカン プロテアーゼ タイセイ ナ イワシ ユライ

抄録

The NH₂-terminal residue of a dipeptide is an important determinant of the resistance to peptidases of porcine small mucosa. NH₂-terminal Val or Ile, and COOH-terminal Trp or Tyr dipeptides had higher angiotensin I converting enzyme(ACE)inhibitory activity and digestive resistance than other dipeptides. We defined Val-Tyr as a main inhibitor in alkaline protease hydrolyzates from sardines. Attempts to isolate and measurement of Val-Tyr were done from the short chain peptides that reduced blood pressure. The content of Val-Tyr was 51 mg per 100 g of the short chain peptides, represented 1.3% of the total ACE inhibitory activity of the short chain peptides. Isolated Val-Tyr was resistant to gastrointestinal proteases. The primary structures of fragments formed from Arg-Val-Tyr by digestive proteases were considerably different, and it was confirmed that the main peptide, Val-Tyr, was formed by intestinal proteases after digestion. The content of Val-Tyr formed from the short chain peptides by intestinal proteases after digestion was less than 10 percent of the original.

収録刊行物

• 日本農芸化学会誌

  日本農芸化学会誌 69 (8), 1013-1020, 1995

  公益社団法人 日本農芸化学会

キーワード

• Medicine (miscellaneous)
• Chemistry (miscellaneous)
• Food Science
• Biotechnology

詳細情報

• CRID: 1390282679483227136
• NII論文ID: 110002791108
• NII書誌ID: AN00196191
• DOI: 10.1271/nogeikagaku1924.69.1013
• COI: 1:CAS:528:DyaK2MXntlajsro%3D
• ISSN: 18836844
• ISSN: 00021407
• ISSN: http://id.crossref.org/issn/00021407
• NDL書誌ID: 3631913
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3631913
• Web Site: https://www.jstage.jst.go.jp/article/nogeikagaku1924/69/8/69_8_1013/_pdf
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