医用磁性ナノビーズのポストゲノム解析時代における新展開  [in Japanese] Prospects for Medical Applications Using Magnetic Beads in the Post-Genomic Era  [in Japanese]

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Author(s)

    • 阿部 正紀 ABE M.
    • 東京工業大学理工学研究科 Graduate School of Science and Engineering, Tokyo Institute of Technology
    • 半田 宏 HANDA H.
    • 東京工業大学生命理工学研究科 Graduate School of Bioscience and Engineering, Tokyo Institute of Technology

Abstract

The end of the genomic-era has resulted in new scientific challenges in the field of biomedical research. In particular, there are increasing demands for the development of high performance, nanometer sized, polymer-coated magnetic beads for use as carriers for high throughput bio-screening (HTBS). The use of HTBS technology will enable not only the collection of bio-receptors and affinity-coupled chemicals (candidates for new drugs) but also the elucidation of mechanisms causing the side effects of drugs. This research will facilitate the development of novel drugs and tailored medicine based on personal genetic information as well as global commercial enterprises. We first present the pertinent background for a fundamental understanding of HTBS, DNA diagnoses, and immunoassays, whose performance can be greatly improved by substituting conventional sub-micron or larger magnetic beads with nanometer sized beads. We then describe our invention that permits polymer coatings or physiologically active molecules to cover/attach to ferrite surfaces by strong chemical bonds during ferrite bead synthesis. As an extension of our technology, we propose the use of high performance magnetic carriers for MRI contrast enhancement, hyperthermia, and drug delivery, which have anti-cancer antibodies immobilized onto their surfaces in order to selectively couple carriers to cancer cells.

Journal

  • Journal of Magnetics Society of Japan

    Journal of Magnetics Society of Japan 28(7), 841-846, 2004-07-01

    日本応用磁気学会

References:  15

Cited by:  5

Codes

  • NII Article ID (NAID)
    110002809814
  • NII NACSIS-CAT ID (NCID)
    AN0031390X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    02850192
  • NDL Article ID
    7020866
  • NDL Source Classification
    ZM35(科学技術--物理学)
  • NDL Call No.
    Z15-398
  • Data Source
    CJP  CJPref  NDL  NII-ELS  NDL-Digital 
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