腫瘍性気道狭窄に対する純エタノール局注療法の試み  [in Japanese] Intratumoral Injection of Absolute Ethanol for Tracheobronchial Stenosis by Tumor  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

気管支鏡を用いた内視鏡的治療法の一つとして, 気管, 気管支の腫瘍性狭窄, 閉塞に対して99.5%エタノール(純エタノール)局注療法を試みた。対象は肺癌7例, 転移性肺癌, 気管癌, 多発性気管乳頭腫各1例の計10例であった。有効症例は10例中6例(60%)であり, 肺癌症例のうち1例は有効, 3例は一時有効で, 他3例は無効であった。転移性肺癌症例は無効であったが, 気管癌, 気管乳頭腫症例では有効であった。有効例での腫瘍の発育は主にポリープ状であり, 無効例では浸潤性狭窄を呈していた。副作用は軽度の咳嗽以外認められなかった。以上から, 気管支鏡下純エタノール局注療法は, 適応をある程度限定すれば, 他療法の制限をともなう悪性腫瘍症例においても姑息的, 対症的治療法としてQOLの改善に有用であると考えた。

Intratumoral injection of absolute (99.5%) ethanol via a flexible bronchofiberscope was attempted on 10 cases with tracheobronchial stenosis or obstruction by neoplasia. Out of 7 cases with lung cancer, ethanol injections were effective in 1 case, and temporarily effective in 3 cases, while they were ineffective in the others. Though the results were ineffective in pulmonary metastasis, effects were obtained in a case of tracheal cancer and one of tracheal papillomatosis was improved. In some cases, radio- or chemotherapy were performed in combination with ethanol injection. There were no complications except for mild cough. This method was effective against polypoid proliferative tumors but ineffective for superficial or submucosally infiltrating tumor. However, even in effective cases, long term prognosis was not so good. Though it is palliative, intratumoral ethanol injection can be useful for bronchoscopic treatment from the standpoint of the patient's quality of life.

Journal

  • The Journal of the Japan Society for Respiratory Endoscopy

    The Journal of the Japan Society for Respiratory Endoscopy 13(3), 249-258, 1991

    The Japan Society for Respiratory Endoscopy

Codes

  • NII Article ID (NAID)
    110002816839
  • Text Lang
    JPN
  • ISSN
    0287-2137
  • Data Source
    NII-ELS  J-STAGE 
Page Top