トリプトファン-ナイアシン代謝経路の中間体とニコチン酸類縁化合物のナイアシン活性効率  [in Japanese] Effciency of the Intermediates of the Tryptophan-Niacin Metabolic Pathway and the Related Compounds of Nicotinic Acid as Niacin in Rats  [in Japanese]

Access this Article

Author(s)

    • 柴田 克己 SHIBATA Katsumi
    • 滋賀県立大学人間文化学部生活文化学科 Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture

Abstract

The nutritional efficiencies of the intermediates of the tryptophan-niacin pathway and the related compounds of nicotinic acid and nicotinamide as a substitute for nicotinic acid were investigated using weanling rats fed the niacin-deficient diet. Judging from the growth response, levels of liver NAD, blood NAD, and urinary excretion of nicotinamide and its metabolites, we have concluded that tryptophan, 3-hydroxyanthranilic acid, quinolinic acid, nicotinamide N-oxide, N'-methylnicotinamide, nicotinuric acid, 3-acetylpyridine, pyridine 3-aidehyde, pyridine 3-methanol, β-picoline, or nicotinic acid N-oxide is approximately 1/10, 1/12, 1/24, 1/5, 1/2, 1/10, 1/10, 1/1, 1/1, 1/10, or 1/2 active as nicotinic acid, however, that N-formylkynurenine, kynurenine, 3-hydroxykynurenine, anthranilic acid, cinchomeronic acid, 3-cyanopyridine, 6-hydroxynicotinic acid, and pyridine 3-sulfonic acid do not have any niacin activity. Only 6-aminonicotinamide of the examined compounds showed the very strong antagonistic activity against niacin.

Journal

  • VITAMINS

    VITAMINS 72(10), 515-522, 1998

    THE VITAMIN SOCIETY OF JAPAN

References:  14

Cited by:  2

Codes

  • NII Article ID (NAID)
    110002843423
  • NII NACSIS-CAT ID (NCID)
    AN00207833
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0006-386X
  • NDL Article ID
    4587344
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-36
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
Page Top