書誌事項
- タイトル別名
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- Possibility of the Biosynthesis of Niacin from D-Aspartic Acid in Mammals
- ホニュウドウブツ ニ オケル D-アスパラギンサン カラ ノ ナイアシン セイゴウセイ ノ カノウセイ
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抄録
Quinolinic acid, a key intermediate in the de novo biosynthesis of niacin, is biosynthesized from L-tryptophan in mammals while it is biosynthesized from L-aspartic acid and dihydroxyacetone phosphate in Escherichia coil. Quinolinate synthetase of E. coli consists of two components A and B proteins. The B protein has been identified as L-aspartic acid oxidase that generates iminoaspartic acid. Iminoaspartic acid is then conjugated with dihydroxyacetone phosphate to generate quinolinic acid by the A protein. In the mammalian liver, unlike in E. coli, D-aspartic acid oxidase has been found, by which also iminoaspartic acid is generated. Significant amounts of D-aspartic acid are contained in tortillas (lime-treated corn) which has been served as anti-pellagra foodstuff. Therefore, we postulated and examined a possibility of the biosynthesis of niacin from D-aspartic acid in mammals. Administration of D-aspartic acid to rats and humans did not increase urinary excretion of niacin and its metabolites. In rats, administration of D-aspartic acid did not improve the growth of weaning rats fed a tryptophan-limiting and niacin free diet. Based on those results, the possibility of biosynthesis of niacin from D-aspartic acid in mammals was denied.
収録刊行物
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- ビタミン
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ビタミン 73 (9), 527-532, 1999
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680762213376
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- NII論文ID
- 110002843919
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 4862371
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
