ビタミンEとアルツハイマー病

• 阿部 皓一

  エーザイ株式会社ビタミンE技術室

• 峰岸 孝次

  エーザイ株式会社ビタミンE技術室

• 美濃 眞

  清恵会病院

書誌事項

タイトル別名

• Vitamin E and Alzheimer Disease
• ビタミン E ト アルツハイマービョウ

抄録

It has been hypothesised that oxidative damage plays an important role in the pathogenesis of Alzheimer disease. Antioxidant substances, such as vitamins E (E, α-tocopherol) and C, have been shown to modify oxidative processes in laboratory experiments and animal trials. Epidemiologic studies have suggested that intake of antioxidant nutrients may be associated with a reduced risk of develop ing Alzheimer disease. A recent clinical trial indicated that E supplementation or/and selegiline sig nificantly slows the progression of Alzheimer disease. Since E was demonstrated to have far fewer adverse effects, it has become a noteworthy nutrient or drug for Alzheimer disease. In this review, we focus on the relation between Alzheimer disease and E, and summarise the presumed mechanisms of E pharmacological action (mainly, anti-oxidant function) and recent epide miologic and clinical studies of E against Alzheimer disease.

収録刊行物

• ビタミン

  ビタミン 74 (3), 113-119, 2000

  公益社団法人 日本ビタミン学会

キーワード

• Alzheimer disease
• vitamin E
• ct-tocopherol
• oxidative damage
• selegiline

詳細情報

• CRID: 1390282680762557440
• NII論文ID: 110002844017
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.74.3_113
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 5327417
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5327417
• Web Site: https://search.jamas.or.jp/link/ui/2000165819
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可