炎症時におけるビタミンAの消耗と肺エイコサノイド産生に対する抑制能

DOI Web Site 被引用文献4件

書誌事項

タイトル別名
  • Consumption of Vitamin A in Inflammation and The Suppression of Leukotrien Synthesis by Vitamin A
  • エンショウジ ニ オケル ビタミン A ノ ショウモウ ト ハイ エイコサノイド

この論文をさがす

抄録

The biological function of vitamin A for defense and suppresion of inflammation induced by varied causes has been investigated with respect to consumption of the vitamin A, and decrease in eicosanoid productions. In clinical study, it was observed that elevation of α_1-acid glycoprotein (AGP) and C-reactive protein (CRP), which are the acute phase reactants, closely related with decrease in vitamin A, RBP and prealbumin (PA) in patient with lower respiratory infection and mucocutaneus lymph node syndrome (MCLS). In rats, it was verified that absorption of vitamin A from the gut and its release from the liver were not suppressed by inflammation induced by burn injury and hypodermoclysis with terpene oil, and then, in the in vitro and in vivo studies, the enhanced consumption of vitamin A would be assumed under the condition accompained by inflammation. In additon, vitamin A suppressed the production of leukotrienes in macrophages from rat lungs after the stimulation with an endotoxin. These findings suggest that vitamin A deprevation is susceptible to infection due to increased production of leukotrienes.

収録刊行物

  • ビタミン

    ビタミン 66 (5-6), 277-288, 1992

    公益社団法人 日本ビタミン学会

被引用文献 (4)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ