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- HARADA Kiyoshi
- Products Research and Development Laboratory, Tanabe Seiyaku Co., Ltd.
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- KOHNO Keiichi
- Products Research and Development Laboratory, Tanabe Seiyaku Co., Ltd.
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- DAIRA Isamu
- Products Research and Development Laboratory, Tanabe Seiyaku Co., Ltd.
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- UTSUMI Isamu
- Products Research and Development Laboratory, Tanabe Seiyaku Co., Ltd.
Bibliographic Information
- Other Title
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- ビタミンB_6にかんする研究 : (II) ピリドキサールおよびピリドキサール・りん酸の経口投与時の吸収および体内での消長
- ピリドキサールおよびピリドキサール・りん酸の経口投与時の吸収および体内での消長
- ピリドキサール オヨビ ピリドキサール リンサン ノ ケイコウ トウヨジ ノ キュウシュウ オヨビ タイナイ デ ノ ショウチョウ
Search this article
Abstract
Changes in the blood and liver B_6 Ievels after oral administration of pyridoxal (PAL) and pyridoxal-phosphate (PALP) (10mg/kg) to rabbit and rat were investigated. It was found that PAL and PALP were well and rapidly absorbed by oral route and appeared in the blood dominantly as 4-pyridoxic acid (PiA) in rabbit and as PAL in rat. Same patterns in the blood elimination process were evidenced in both PAL and PALP administration. Circulation experiments using rat intestine in situ as well as experiments by everted sac in vitro revealed that PAL was absorbed from upper small intestine and by part from stomach and PALP was hydrolysed in the intestine and absorbed as PAL. On the basis of these findings, the feature of bioavai-labilities of PAL and PALP as well as their absorption mechanisms are discussed. (Received July 7,1971)
Journal
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- VITAMINS
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VITAMINS 44 (4), 207-212, 1971
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680787239168
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- NII Article ID
- 110002878547
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 8424985
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed