Preparation and Properties of a Glucose Biosensor Based on an Osmium-Complex Modified Polypyrrole.

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  • MOTONAKA Junko
    Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
  • YABUTANI Tomoki
    Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
  • MARUYAMA Kenichi
    Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
  • SHIOMI Tokuo
    Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
  • TATEISHI Norio
    Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima
  • MISHIMA Yuji
    Faculty of Pharmaceutical Sciences, The University of Tokushima

Bibliographic Information

Other Title
  • オスミウム錯体を用いるポリマー修飾グルコースセンサーの試作とその電気化学的特性評価
  • オスミウム サクタイ オ モチイル ポリマー シュウショク グルコースセンサー ノ シサク ト ソノ デンキ カガクテキ トクセイ ヒョウカ

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Abstract

A novel glucose sensor base on an osmium-complex modified polypyrrole was prepared and evaluated. Four new-type osmium-complexes ([Os(bpy)2(py(4)-bpy)]2+/3+, [Os(bpy)2(py(3)-bpy)]2+/3+, [Os(bpy)2(pyro-pri)Cl]+/2+, and [Os(bpy)2(vi-bpy)]2+/3+) were synthesized, and the kinetic parameters analyzed. A hydrophilic redox polymer with an osmium-complex was modified by electrolytic copolymerization on the surface of a platinum electrode. The effects of the polymer concentration, times of the scan, dissolved oxygen, and concomitant compounds, and a calibration curve for measurements of glucose were analyzed. The catalytic currents of synthesized osmium-complexes were observed. The relationship between glucose and the oxidation current was examined using the sensor under the optimum conditions. A linear relationship was obtained over the range of 0.9∼100 mmol dm-3 glucose. It was measured in the presence of ascorbic acid or uric acid. These compounds did not affect the response current. The lifetime of the sensor was also examined. The analytical values were constant for 9 days when the sensor was stored in a pH 7.07 phosphate buffer solution at 4°C.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 51 (12), 1165-1170, 2002

    The Japan Society for Analytical Chemistry

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