Study of Vascular Lesions in Experimental Renal Hypertension : WITH REFERENCE TO RELATIONSHIP BETWEEN VASCULAR LESION AND ARTERIOSCLEROSIS

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  • 実験的腎性高血圧症に於ける血管障害の研究 : 特に動脈硬化症との関係に就て
  • 実験的腎性高血圧に於ける血管障害の研究
  • ジッケンテキジンセイ コウケツアツ ニ オケル ケッカン ショウガイ ノ ケンキュウ

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Abstract

The production of experimental renal hypertension was first reported in 1934 by H. Goldblatt. According to recent study, if the renal arteries were moderately constricted by modified Goldblatt's method, the cerebral massive haemorrhage occurred in the experimental hypertensive rabbits. However, the haemorrhages were observed not only in the brain but also in the other organs. Arteriolar fibrinoid necrosis was one of the chief histological findings of the vascular lesions in these experiments. This vascular lesion resembled the arteriolar lesions in the malignant hypertension, but it was also similar to vascular lesions which were observed in the apoplectic brain.In this report, following two series of experiments were performed in order to study the relationship between the arteriosclerosis and the fibrinoid necrosis.In the first series, Goldblatt's operations were performed in the rabbits prepared by the arteriosclerosis-producing procedures, namely the daily subcutaneous injection of 0.2 cc of a adrenaline for 3 months or the cholesterol feeding for 3 months (0.5 gr daily). In these arteriosclerotic rabbits, the cerebral massive haemorrhage and the fibrinoid necrosis following the Goldblarr's operation were less frequent than in the group not prepared by the arteriosclerosis-producing procedures. (Table 1, 2, 3.)In the second series, experimental hypertensive rabbits were divided into two groups. One group consisted of the rabbits which died acutely within a week after the Goldblatt's operation and another group consisted of the hypertensive rabbits with long survival. The vascular lesions in both groups were compared by the histological study. (Table 4). In the acute cases, the fibrinoid necrosis was observed in the smaller arterioles and many of them were so severe to affect all layers of the blood vessel. Fibrosis of the vascular wall not observed in this group. In the chronic cases, the fibrinoid necrosis was observed in larger arterioles and severe lesion was less frequently observed than in the acute cases. In some cases, fibrinoid substance appeared only in subintimal portion of the blood vessels. Fibrosis was marked in many arteriolar walls, which resembled the arteriolosclerosis in the organs of aged people. Clinical experience shows that the malignant hypertension is most frequent in 30-50 years old and rare in the aged. Pickering suggested that the organic arterial changes might protect the arteriolar necrosis and Nishimori reported that the fibrinoid necrosis never occurred in the arteriosclerotic vessels with fibrous thickening. Above-mentioned experiments supported their opinions.I think the foregoing organic arterial changes can make the fibrinoid necrosis mild and the healing process of the fibrinoid necrosis may produce a type of the arteriolosclerosis.

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