Low-Grade Inflammation, Thrombogenicity, and Atherogenic Lipid Profile in Cigarette Smokers
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- Yasue Hirofumi
- Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Ag-ing Research Institute
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- Hirai Nobutaka
- Department of Cardiovascular Medicine, Kumamoto University School of Medicine
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- Mizuno Yuji
- Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Ag-ing Research Institute
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- Harada Eisaku
- Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Ag-ing Research Institute
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- Itoh Teruhiko
- Division of Cardiology, Kumamoto Kinou Hospital, Kumamoto Ag-ing Research Institute
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- Yoshimura Michihiro
- Department of Cardiovascular Medicine, Kumamoto University School of Medicine
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- Kugiyama Kiyotaka
- Department of Cardiovascular Medicine, Kumamoto University School of Medicine
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- Ogawa Hisao
- Department of Cardiovascular Medicine, Kumamoto University School of Medicine
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Abstract
Background Cigarette smoking is one of the major risk factors for atherosclerotic coronary disease, but the precise mechanism(s) by which cigarette smoking promotes atherosclerosis remains unknown. As there is now increasing evidence that atherosclerosis is an inflammatory condition, the present study investigated whether inflammation exists in smokers. Methods and Results The inflammatory markers and lipid profiles were compared among a current-smoker group (210 patients, mean age 61.8±11.0 years), past-smoker group (115 patients, 67.1±9.0 years) and never-smoked group (113 patients, 68.2±10.7 years), all of whom had no apparent signs of inflammation. The respective levels of blood leukocytes, platelets, C-reactive protein and fibrinogen were significantly higher in current-smokers than in the never-smoked group (6,600±1,723 /μl vs 5,638 ±1,313 /μl p<0.01; 22.7±6.8 ×104 /μl vs 18.7 ±7.4×104 /μl, p<0.01; 3.50±4.91 mg/L vs 1.92±3.02 mg/L, p<0.01; 334.2±90.9 mg/dl vs 314.7±80.2 mg/dl, p<0.05). The respective levels of plasma triglycerides, remnant-like particle cholesterol and apolipoprotein-B were significantly higher and that of high-density lipoprotein cholesterol significantly lower in the current-smokers than in the never-smoked group (152.4±96.2 mg/dl vs 120.5±58.1 mg/dl, p<0.01; 5.4±6.3 mg/dl vs 3.8±2.0 mg/dl, p<0.05; 101.6±23.7 mg/dl vs 95.0±21.2 mg/dl, p<0.05; 45.2±12.3 mg/dl vs 50.6±15.6 mg/dl, p<0.01). Past smokers had intermediate values between those of current-smokers and never-smoked. Conclusions Low-grade inflammation, atherogenic dyslipidemia, and hypercoagulability are present in smokers compared with those who have never smoked among subjects without apparent inflammation who underwent coronary angiography on suspicion of coronary artery disease. (Circ J 2006; 70: 8 - 13)<br>
Journal
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- Circulation Journal
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Circulation Journal 70 (1), 8-13, 2006
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001205105497600
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- NII Article ID
- 110002978452
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- NII Book ID
- AA11591968
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- COI
- 1:STN:280:DC%2BD2MnovVSmtw%3D%3D
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- ISSN
- 13474820
- 13469843
- http://id.crossref.org/issn/13469843
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- PubMed
- 16377917
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed