B-2 無毒・無刺激性モノマーの開発に関する基礎的研究 : 1.カルボキシル基置換フェニルメタクリレートの細胞回復度について

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  • Studies on the development of irritation -and toxicity-free monomers : 1.Cytotoxicity of methacryloyloxybenzoic acid and phenyl methacrylate assessed by the cell recovery test.

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Ortho-, meta- and para-isomers of methacryloyloxybenzoic acid were synthesized by condensation reaction between methacryloyl chloride and the corresponding hydroxybenzoic acids, and phenyl methacrylate was also synthesized.After these products were identified by elemental an alysis and IR and NMR spectroscopies, their cytotoxiclty was examined by the cell recovery test using HEp-2 cells and L-929 cells.The paraisomers of methacryloyloxybenzoic acid were found not to be cytotoxic, while phenyl methacrylate and TEGDMA showed moderate-to-severe cytotoxicity.The variable solubility of these monomers in medium is considered to play a role in their different cytotoxicities.

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