虚弱下顎骨に対するカルシウム療法に関する病理組織学的および超微形態学的研究 : とくに骨基質形成

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  • A Histopathological and Micromorphological Study on Calcium Treatment for Debilitated Mandibles : Especially Formation of Bone Matrix

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Three-week old male rats of Wistar strain were given calcium-deficient food and debilitated mandibles were induced in them. The rats were then given a calcium-deficient diet + a high calcium diet or a calcium-deficient diet + a standard diet. The effect on formation of bone matrix in the mandible at growth stage was investigated after five weeks of maintenance. The results were as follows : I. Histopathological findings In the control group, findings of active bone remodeling were observed. At the same time, at the portion corresponding to enamel organ, small resorption cativities were observed in succession. In the calcium-deficient diet group, as compared with the control group, a considerable decrease in bone quantity was seen and the whole of the osseous layer corresponding to enamel organ showed large and small resorption cavities in the whole area. The high calcium diet group, as compared with the calcium-deficient diet group, showed findings of extensive boen remodeling of transition from bone resorption to bone formation. In the standard diet group, as compared with the high calcium diet group, bone matrix became dense and reconstruction of bone construction by bone remodeling was active on the whole. II. Scanning electron microscope findings In the control group, the surface of bone matrix formation was relatively flat and smooth. The surrounding matrix of the bone lacuna was composed of segments of bundles of collagen fibrils. In the calcium-deficient diet group, bone resorption surfaces were more extensively seen than bone matrix formation surfaces. In the high calcium diet group, as compared with the calcium-deficient diet group, collagen fibrils running in a given direction appeared. In standard diet group, as compared with the high calcium diet group, findings of decarease in bone resorption images were seen and collagen fibrils running in a given direction tended to increase. On the basis of the foregoing findings, in calcium treatment for debilitated mandibles, the standard diet group, as compared with the high calcium diet group, showed decrease in bone resorption images and active reconstruction of bone construction by bone remodeling.

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