虚弱歯槽骨に対する高カルシウム食・カルシトニンの併用療法に関する実験的研究

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  • An Experimental Study on a Combined Treatment Method of a High-calcium Diet and Calcitonin on Alveolar Bone Debility

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Three-week-old male Wistar rats were maintained on a non-calcium diet or a low-calcium diet and bone debility was induced in them. Then the rats were given a high-calcium diet and eel calcitonin (ECT), and the effect on the alveolar bone was investigated. The results were as follows : 1. Analysis of radiological bone shadow density Al equivalence of the bone shadow density decreased in the order of the control group, the low-calcium diet, high-calcium diet and ECT group, the low-calcium diet and standard diet group, the non-calcium diet, high-calcium diet and ECT group. 2. Characteristic and quantitative analyses In every group, the characteristic X-ray image showed higher density Ca than P in any individual trabeculae. 3. Light microscopic findings As compared with the control group, higher bone absorption and higher decrease in bone quantity were observed in the non-calcium diet, high-calcium diet and ECT group and the low-calcium diet and standard diet group. In the low-calcium diet, high-calcium diet and ECT group, bone construction was accelerated highest next to the control group. 4. Scanning electron microscopic findings As compared with the control group, wider expansion of bone marrow and more extensive bone absorption findings were observed in the non-calcium diet, high-calcium diet and ECT group and the low-calcium diet and standard diet group. The low-calcium diet, high-calcium diet and ECT group showed morphologically similar findings to those of the control group. On the basis of the foregoing results, a combined treatment method of a high-calcium diet and calcitonin for alveolar bone debility has proved to accelerate remodeling in calcification of bone and bone construction.

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