老年期ラットの虚弱脛骨骨幹皮質骨における食餌療法に関する X 線学的骨塩量および病理組織学的研究 : 骨基質形成について

• 福井 正彦

  九州歯科大学大学院歯学研究科

書誌事項

タイトル別名

• Densitometric and Histopathological Study of Dietary Treatment Effect on Bone Loss of Diaphysial Cortex of Tibita in Aged Rats : on Formation of Bone Matrix

抄録

Adequate calcium intake is necessary for maintainance of bone mass in prevention of osteoporotic fracture, which has become a major social problem in the aged. The bone matrix formation of diaphysial cortex was investigated, using male Wistar rats of 13 months of age corresponding with the aged in human beings, in which bone loss had resulted by calcium deficiency and low calcium feeding and followed by supplementation with standard dietary. The results were as follows. I. Body weight No significant difference was revealed between control, calcium deficiency, and low calcium groups. II. Radiographic densitometric findings There was no significant difference identified of medial and interosseous cortexes between the control, calcium deficiency, and low calucium groups. Also, the differences of the sum of both medial and interosseous cortexes was shown to be not significant statistically (p>0.05) between control and calcium deficiency, control and low calcium, calcium deficiency and low calcium groups. III. Radiographic microanalysis findings Calcium density was shown to be higher than phosphorus within medial and interosseous cortical bone in all the control, calcium deficiency, and low calcium groups. IV. Histopathological findings Calcium deficiency and low calcium group decreased thickness of medial and interosseous cortex, compared with control group. Bone resorption was evident in inner and outer circumferential lamellae and bundle bone. Haversian system and osteocytic lacunae increased, and bundle bone decreased significantly. V. Hemotologic findings Chlorine level was shown to be significantly lower in calcium deficiency than in control group (p<0.01). Low calcium group showed lower CPK and higher ALP level than control group (p<0.05). Based on these results, inner and outer circumferential lamellae and bundle bone decreased substantially even when the balanced calcium-containing dietary treatment had been provided in long term for calcium deficiency and low calcium intake induced bone loss in the age of 13 months.

収録刊行物

• 九州歯科学会雑誌

  九州歯科学会雑誌 52 (1), 90-108, 1998

  九州歯科学会

キーワード

• Aged Rat
• Cortex of tibita diaphysis
• Dietary treatment
• Bone Matrix
• Rat

詳細情報

• CRID: 1390001206347547264
• NII論文ID: 110003005748
• NII書誌ID: AN00054335
• DOI: 10.2504/kds.52.90
• ISSN: 18808719
• ISSN: 03686833
• Web Site: https://www.jstage.jst.go.jp/article/kds/52/1/52_KJ00003277891/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998138520
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可