尿道の自律神経支配に関する薬理学的研究 STUDIES OF AUTONOMIC RECEPTOR FUNCTION IN CANINE URETHRA
The function of autonomic receptors was studied using an isometric in vitro technique and urethral smooth muscle strips isolated from adult female dogs. The urethral pressure profile measurement method of Brown and Wickham was also employed with some modifications in female dogs. All agents used were intravenously injected. In invitro studies, noradrenalin and adrenalin produced a dose-dependent contraction which was blocked by phentolamine. The contraction in the transversal strips tended to be stronger than that in the longitudinal strips. Isoproterenol caused a weak relaxation which was blocked by propranolol. Acetylcholine provoked a weak contraction which was blocked by atropine. These results indicate that the urethral smooth muscle contain alpha-and beta-adrenergic receptors and muscarinic cholinergic receptor, and there is a dominancy of alpha-adrenergic receptor in reaction.
日本泌尿器科学会雑誌 71(1), p33-50, 1980-01