尿道の自律神経支配に関する薬理学的研究 STUDIES OF AUTONOMIC RECEPTOR FUNCTION IN CANINE URETHRA

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抄録

The function of autonomic receptors was studied using an isometric in vitro technique and urethral smooth muscle strips isolated from adult female dogs. The urethral pressure profile measurement method of Brown and Wickham was also employed with some modifications in female dogs. All agents used were intravenously injected. In invitro studies, noradrenalin and adrenalin produced a dose-dependent contraction which was blocked by phentolamine. The contraction in the transversal strips tended to be stronger than that in the longitudinal strips. Isoproterenol caused a weak relaxation which was blocked by propranolol. Acetylcholine provoked a weak contraction which was blocked by atropine. These results indicate that the urethral smooth muscle contain alpha-and beta-adrenergic receptors and muscarinic cholinergic receptor, and there is a dominancy of alpha-adrenergic receptor in reaction.

収録刊行物

  • 日本泌尿器科学会雑誌

    日本泌尿器科学会雑誌 71(1), p33-50, 1980-01

    社団法人日本泌尿器科学会

各種コード

  • NII論文ID(NAID)
    110003046854
  • NII書誌ID(NCID)
    AN00196577
  • 本文言語コード
    JPN
  • ISSN
    00215287
  • NDL 記事登録ID
    2208323
  • NDL 刊行物分類
    SC611(泌尿器科学)
  • NDL 雑誌分類
    ZS39(科学技術--医学--皮膚科学・泌尿器科学)
  • NDL 請求記号
    Z19-203
  • データ提供元
    NDL  NII-ELS 
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