肺癌化学療法における吃逆に関する検討  [in Japanese] Hiccup Observed during Chemotherapy for Lung Cancer  [in Japanese]

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Abstract

肺癌患者に対し, シスプラチンを中心とする化学療法を施行した際, 5HT_3受容体拮抗剤とステロイド剤の併用による標準的な予防的制吐療法を行った場合, 経験的に高頻度に吃逆が観察される.我々は1997年4月から約1年間に全身化学療法を施行した13例の肺癌患者について, 吃逆の発生状況をretrospectiveに検討した.CDDPベースの化学療法は9例に行われ, 前例で5-HT_3受容体拮抗剤とステロイド剤の併用による制吐療法が行われていた.このうち1例を除く8例, 総投与コース数24コース中11コースで吃逆が認められた.吃逆はCDDP投与開始後18〜42時間後(中央値26時間後)に発生し, 1〜37時間(中央値11時間)持続し, 最長でも58時間後には停止した.CDDPを使用しなかった4例では吃逆を認めなかった.CDDPベースの化学療法に標準的制吐療法を行った場合, 高頻度に吃逆を認めることが明らかとなった.

Objective : To ascertain the clinical impression that hiccups are frequently observed during cisplatin (CDDP)-based chemotherapy for lung cancer, and to clarify onset, duration and therapeutic intervention of this troublesome symptom. Methods : Thirteen patients who received systemic chemotherapy for lung cancer from April 1997 to May 1998 were included in this retrospective analysis. The information about ocurrence of hiccup was obtained from medical and nursing records. Results : Nine patients received CDDP-based chemotherapy. They simultaneously received prophylactic antiemetic therapy with a 5-HT_3 receptor antagonist and dexamethasone. Hiccups were observed in 8 of 9 patients and in 11 courses among a total of 24 courses. Hiccups began at 18 to 42 hours (median 26 hours) after starting CDDP infusion, and lasted for 1 to 37 hours (median 11 hours). None of the four patients who received only non-CDDP based therapy experienced hiccups. Conclusion : Hiccups were frequently observed during CDDP-based chemotherapy for lung cancer

Journal

  • Japanese Journal of Lung Cancer

    Japanese Journal of Lung Cancer 40(1), 33-37, 2000-02-20

    The Japan Lung Cancer Society

References:  14

Cited by:  1

Codes

  • NII Article ID (NAID)
    110003111426
  • NII NACSIS-CAT ID (NCID)
    AN00203978
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03869628
  • Data Source
    CJP  CJPref  NII-ELS 
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