Comparison of the Effects of Different Schedules of rG-CSF Administration after Chemotherapy in Patients with Lung Cancer.

• Yoshii Chiharu

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Morimoto Yasuo

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Nikaido Yoshihiko

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Tao Yoshiaki

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Tsuda Tohru

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Nagata Nobuhiko

  Division of Respiratory Disease, University of Occupational and Environmental Health

• Kido Masamitsu

  Division of Respiratory Disease, University of Occupational and Environmental Health

Bibliographic Information

Other Title

• 肺癌化学療法におけるｒＧ－ＣＳＦ投与開始時期による効果の検討

Abstract

rG-CSF is administered with antineoplastic drugs in patients with lung cancer in order to increase the level of white blood cell (WBC) counts or shorten the duration of leukocytopenia. However, it has not been determined when it is best to commence to administer r G-CSF. In this study, we investigated WBC counts at the nadir and the duration of leukocytopenia in three different chemotherapy regimens among four groups classified by commencement of rG-CSF administration, namely, Group A: without rGCSF, Group B: commencement from the day when WBC counts decreased below 2000/mm³, Group C: commencement from day 2, Group D: commencement from day 5. In group D, WBC counts at the nadir were significantly increased compared with group A and were maintained above 2000/mm³ in all cases. In groups B and C, the duration of leukocytopenia was shortened compared with group A in the patients given the same chemotherapy regimens. Our results support recommending starting rG-CSF administration from day 5 in these chemotherapy regimens to increase WBC counts at the nadir and shorten the duration of leukocytopenia.

Journal

• Haigan

  Haigan 33 (6), 917-923, 1993

  The Japan Lung Cancer Society

Keywords

• rG-CSF
• Leukocytopenia
• Lung cancer
• Cancer chemotherapy

Details

• CRID: 1390282679657438464
• NII Article ID: 110003113091
• NII Book ID: AN00203978
• DOI: 10.2482/haigan.33.917
• ISSN: 13489992
• ISSN: 03869628
• Web Site: http://www.jstage.jst.go.jp/article/haigan1960/33/6/33_6_917/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1994169331
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed