肺癌におけるＣａｒｂｏｐｌａｔｉｎ至適投与量の予測式に関する検討

• 坂本 直子

  広島赤十字・原爆病院呼吸器科

• 大道 和宏

  広島赤十字・原爆病院呼吸器科

• 杉原 基弘

  広島赤十字・原爆病院呼吸器科

• 石井 尚子

  広島赤十字・原爆病院呼吸器科

• 坂尾 直子

  広島赤十字・原爆病院呼吸器科

• 有田 健一

  広島赤十字・原爆病院呼吸器科

書誌事項

タイトル別名

• Evaluation of Predictive Formulas of Carboplatin Clearance to Calculate the Optimal Dosage in Japanese Lung Cancer Patient.

抄録

Carboplatin (CBDCA) is an agent used frequently in the treatment of various malignancies. Its major hematologic toxicity, thrombocytopenia, is largely dependent on the area under the concentration-time curve (AUC), so it is important to estimate prospectively the individual clearance of plasma carboplatin (CL). CBDCA by intravenous drip infusion over 1 h at a dose of 500mg/m² was given to 24 untreated patients with non-small cell lung cancer at the Hiroshima Red Cross Hospital between April 1992 and July 1996, and pharmacokinetics examination for plasma carboplatin was made. We retrospectively evaluated Chatelut's formula, Calvert's formula and Jelliffe's formula to determine whether they could be applicable to Japanese patients with lung cancer. Although the measured AUC significantly correlated with the degree of thrombocytopenia, AUC estimated by the formulas (AUCest) showed no significant correlation. Furthermore, the CL calculated back was overestimated. Therefore, we concluded that it may be necessary to establish a predictive equation of CBDCA CL for Japanese patients. Because there are significant correlations between age, Ccr24h, and CBDCA CL, we tried to derive a predictive equation from the data of 23 patients by multiple regression analysis. Estimated CL (ml/min) =0.52×Ccr24h-2.62×age+223.3. The CL calculated from this equation closely correlated with the measured CL (r=0.71, p<0.01), however, there are some bias between them (MPE%=7.61, RMSE%=23.3). This study may be significant as the first trial of prediction of CBDCA CL for Japanese patients, and a larger-scale study would be needed to derive the precise formula of the optimal CBDCA dosage for Japanese patients with lung cancer.

収録刊行物

• 肺癌

  肺癌 39 (1), 27-33, 1999

  特定非営利活動法人 日本肺癌学会

キーワード

• Carboplatin
• Calvert's formula
• Jelliffe's creatinin clearance
• Chatelut's formula
• AUC

詳細情報

• CRID: 1390001204679174400
• NII論文ID: 130003920261
• NII論文ID: 110003114863
• NII書誌ID: AN00203978
• DOI: 10.2482/haigan.39.27
• ISSN: 13489992
• ISSN: 03869628
• Web Site: http://www.jstage.jst.go.jp/article/haigan1960/39/1/39_1_27/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999221224
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可