肺扁平上皮癌の発癌過程とDNA分析

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  • 加藤 治文
    東京医科大学外科学教室
  • 早田 義博
    東京医科大学外科学教室
  • Nasiell Magnus
    Cytology Laboratory, Pathology II, Sabbatsbergs hospital, Karolinska Institute
  • Auer Gert
    Cytology Laboratory, Pathology II, Sabbatsbergs hospital, Karolinska Institute
  • Zetterberg Anders
    Cytology Laboratory, Pathology II, Sabbatsbergs hospital, Karolinska Institute
  • Karlen Lena
    Cytology Laboratory, Pathology II, Sabbatsbergs hospital, Karolinska Institute

書誌事項

タイトル別名
  • The process of the development of pulmonary squamous cell carcinoma and cytophotometric DNA analysis
  • In respect of squamous cell metaplasia of bronchial epithelium, Carcinoma in situ and keratinized squamous cell carcinoma
  • 気管支上皮扁平上皮化生, Carclnoma in situ及び角化扁平上皮癌の細胞について

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抄録

Recently, squamous cell metaplasia of the bronchial epithelium is being given attention in regard to the carcinogenesis of bronchogenic squamous cell carcinoma. It is apparent that various degrees of atypia occur in the metaplastic squamous cells and corresponding histopathologic lesions.<BR>The study of such changes gives the impression that a series of progressive epithelial changes with increasing cellular atypia may occur in the bronchial epithelium. Also correlation between the occurrence of atypical squamous metaplasia and bronchogenic carcinoma has been suggested.<BR>In this present investigation, cytophotometric DNA analysis was performed in order to investigate the relationship between them. It seems that increasing cytological atypia of various cell populations is related to a decrease of the fraction of cells with diploid and tetraploid values and a corresponding increase of the fraction of the cells with heteroploid DNA content. It is suggested that the results presented herein support the supposition that increasing cellular atypia in metaplastic cells reflect a sequence of cellular events in squamous bronchial epithelium finally resulting in squamous bronchogenic carcinoma.<BR>The results of the characteristic histograms of each grade of squamous cell metaplasia in the bronchial epithelium also indicates that cytophotometric analysis of DNA contents can provide us with objective criteria in addition to the subjective morphological criteria of the grade of atypical squamous cell metaplasia.

収録刊行物

  • 肺癌

    肺癌 17 (4), 267-279, 1977

    特定非営利活動法人 日本肺癌学会

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