横紋筋肉腫肺転移症例のヌードマウス株，および培養細胞株

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  • Nude Mouse Line and Cell Line of Pulmonary Metastasis of Rhabdomyosarcoma.

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A case of rhabdomyosarcoma, its nude mouse line and cell line were presented. A 21-year-old woman who had undergone tumor resection of the labium majus pudendi and had been diagnosed as rhabdomyosarcoma 14 months previously, developed multiple pulmonary nodules and was admitted to our department because of cough and dyspnea. She died on the 34th day after the commencement of combined chemotherapy which showed little effects. Autopsy revealed multiple pulmonary metastases of alveolar type rhabdomyosarcoma with no evidence of local relapse. The nude mouse line and cell line which were successfully established from autopsy specimens showed karyotype of 47, XX, +5, +7, -13, -21, -22, -22, del (2) (q33), +der (21) t (21;?) (p11;?), +marl and +mar2. Doubling times of a pulmonary metastasis, the nude mouse line and the cell line were 17 days, 4.0 days and 1.5 days, respectively. A polar solvent differentiating agent, dimethylsulfoxide (DMSO) was found to alter the morphological features of the cultured cells from spherical shape to a myoblast-like appearance.<BR>These preliminary studies suggest that this model may be promising to provide valuable experimental system in vivo and in vitro, especially for biological investigations of cell differentiation and drug sensitivity of rhabdomyosarcoma.

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  • 肺癌

    肺癌 32 (6), 889-896, 1992

    特定非営利活動法人 日本肺癌学会

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