細胞診断学的にみた肺巨細胞癌 [in Japanese] Giant cell carcinoma of the lung A cytological evaluation [in Japanese]
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肺巨細胞癌の組織像は横紋筋肉腫に類似し転移が多臓器に及ぶ悪性度の高い性格をもつ. 著者らは, 本型の直接採取法による新鮮癌細胞の形態を検討した. 大小不同が著しく多核, 単核巨細胞が優勢でCytophagocytosisや有糸分裂像が多い. また細胞間結合に乏しい多角, 円型細胞もみられ, 核は分葉, 陥凹, 出芽, くびれなど多形性が著しい. 多くの細胞は, PAS反応陽性である. また各種の巨細胞の鑑別診断についても検討を加えた.
In 1958, Nash and Stout called attention to a type of primary lung cancer comprised principally of giant cells and variable focuses of anaplastic frequently mesenchymal-like components resembling rhabdomyosarcoma or osteosarcoma.<BR>Giant cell carcinoma of the lung occurred at a younger age, exhibited widespread metastases, and pursed a more rapid, fulminant course than histological variants. Its lower resectability rate compared to other lung carcinomas.<BR>We studied materials before radiation and chemotherapy in five cases of giant cell carcinoma of the lung obtained by bronchoscopic brushing method and transthoracic aspiration. These materials were informative for study of fresh cancer cells.<BR>Chest x-ray findings in all cases a nodular shadow.<BR>Morphological features were studied with stain methods such as Pap., Giemsa, PAS, Mucicarmin, and Alcianblue reaction.<BR>Multinucleated and uninucleated bizzarre giant cells showed to phagocytize neutrophils, and debris and uneven dispersed distribution or a pooly cohesive groups but never in tight clusters. Occasionally cancer cells were found in necrotic substances. The cancer cells were round or smooth but showed lobulation, budding, indentation and constriction, and chromatin was coarsely or fine and rich. The nucleoli were round and small.<BR>In differential diagnosis, we studied on similarity and difference with epidermoid carcinoma, choriocarcinoma, rhabdomyosacoma, osteosarcoma, Langhans's giant cell and histiocyte.
Haigan 18(1), 21-30, 1978
The Japan Lung Cancer Society