小腸再発転移巣からのＧ‐ＣＳＦ産生を認めた原発性肺癌の１例

• 江口 圭介

  川崎市立川崎病院呼吸器外科 慶應義塾大学医学部外科

• 小林 紘一

  川崎市立川崎病院呼吸器外科

書誌事項

タイトル別名

• Granulocyte-colony Stimulating Factor (G-CSF) Producing Recurrent Tumors of the Small Bowel in a Patient With Lung Cancer.

抄録

Background. Leucocytosis arising from a high blood concentration of tumor-produced G-CSF andmetastasis to the small bowel are both rare events in patients with lung cancer. We report a case with G-CSF producingmetastatic tumors of the small bowel identified after induction chemotherapy for a primary lung cancer. Case. A 55-year-old man was with an abnormal shadow on his chest X-ray film was admitted and non-small cell lung cancer was diagnosed.Chemotherapy with carboplatin at AUC 5 (day 1) and CPT-11 (60mg/m²; days 1, 8, 15) was repeated 3 times (2 courses before the operation and one course after the operation) every 4 weeks. The primary lesion was almost completelyresected by a left upper lobectomy with lymph node dissection. Tumor recurrence in mediastinal lymph nodeswas diagnosed 5 months after the operation. Chemotherapy with gemcitabine (800mg/m² weekly) was started soon after, but the patient developed leukocytosis (56100/mm³) with a high serum level of G-CSF and massive melena from metastatictumors of the small bowel. An emergency bowel resection was performed to stop the bleeding, and the peripheralwhite blood cell count and serum G-CSF level were decreased immediately after surgery. Immunohistochemicalstaining revealed G-CSF production not in the primary lung cancer tissue, but in the metastatic intestinal tumor tissue.The bleeding also decreased temporarily, but the patient died 10 months after the first operation. Conclusion. G-CSFproduction mainly occurred in the recurrent tumor of the small bowel after the start of induction chemotherapy for primarylung cancer. At this point, the clinical course is very unique among reported cases of G-CSF producing lung cancers

収録刊行物

• 肺癌

  肺癌 42 (6), 619-623, 2002

  特定非営利活動法人 日本肺癌学会

キーワード

• 術前化学療法
• 肺癌小腸転移
• G-CSF産生腫瘍

詳細情報

• CRID: 1390282679657429504
• NII論文ID: 130003754679
• NII論文ID: 110003137936
• NII書誌ID: AN00203978
• DOI: 10.2482/haigan.42.619
• ISSN: 13489992
• ISSN: 03869628
• ISSN: http://id.crossref.org/issn/03869628
• Web Site: http://www.jstage.jst.go.jp/article/haigan1960/42/6/42_6_619/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003123325
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可