粘液産生肺腺癌の臨床病理学的検討　杯細胞型腺癌切除例について

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タイトル別名
  • Clinicopathological Studies of Goblet Cell Type Mucus-producing Adenocarcinoma of the Lung.
  • 杯細胞型腺癌切除例について

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Twenty-nine resected cases of goblet cell type adenocarcinoma of the lung were examined clinicopathologically. The ages of 12 males and 17 females varied from 42 to 80 years with the mean age being 63.8. Ten patients complained of cough, sputum and/or bloody sputum. There were 14 smokers and 14 non-smokers and in one case no information was available. The X-ray and macroscopic findings revealed 10 diffuse type and 19 nodular type adenocarcinomas. In the 19 nodular type cases, the carcinomas were found in both lower lobes of the lung, originating in the right lower lobe in 15 cases. Lobectomy was performed in 22 cases, bilobectomy in 5 cases, and in 1 case each, pneumonectomy and segmentectomy. Pathologically 14 cases were found to be in stage I and 15 cases were in stage N. All stage N patients had intrapulmonary metastases, and 9 of the 10 diffuse type cases were in stage N. The 5-year survival rate of nodular type (n=18) was significantly higher than that of the diffuse type (n=9, p <0.01). Pure goblet cell type adenocarcinoma had a better prognosis than that of mixed goblet cell type, although the difference was not statistically significantly. Each case of goblet cell type adenocarcinoma matched three cases of Clara cell type and bronchial surface epithelial cell (BSE) type adenocarcinoma with regard to sex, age and stage. Goblet celltype adenocarcinomas showed better prognosis than Clara cell and BSE type adenocarcinomas, but there was no statistical significance. These results indicated that goblet cell type adenocarcinomas are clinicopathologically different from most adenocarcinomas of other cell types.

収録刊行物

  • 肺癌

    肺癌 32 (4), 507-516, 1992

    特定非営利活動法人 日本肺癌学会

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