An Immunohistochemical Analysis of Gastric B-cell Lymphomas: Stromal Cells Exhibit Peculiar Histogenesis in Gastric B-cell Lymphomas

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  • Hasui Kazuhisa
    The Second Department of Anatomy, Kagoshima University Faculty of Medicine
  • Li Fang
    Department of Pathology, China Medical University
  • Jia Xin-Shan
    Department of Pathology, China Medical University
  • Nakagawa Masanori
    Department of Neurology and Gerontology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine
  • Nakamura Takao
    Kagoshima Institute of Preventive Medicine
  • Yonezawa Suguru
    The Second Department of Pathology, Kagoshima University Faculty of Medicine
  • Izumo Shuji
    Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Kagoshima University Faculty of Medicine
  • Akiyama Shin-ichi
    The Institute of Chemotherapy, Kagoshima University Faculty of Medicine
  • Sato Eiichi
    Kagoshima University
  • Murata Fusayoshi
    The Second Department of Anatomy, Kagoshima University Faculty of Medicine

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Abstract

Anti-Helicobacter pylori (HP) therapy succeeded in regressing gastric B-cell lymphomas (gBL) with a close relation to infestation of HP, although the exact mechanism of anti-HP therapy in gBL has not yet been clarified. In order to see a part of the mechanism, this study analyzed stromal cells in 34 gBL cases comprised of 11 cases of mucosa-associated lymphoid tissue (MALT) type and 24 cases of diffuse large B-cell lymphoma (DLBL) by means of immunohistochemistry of CD3, CD5, CD79a, CD68, CD21, S100 protein, thymidine phosphorylase (TP) and inducible nitric oxide synthase (iNOS). Numerous CD68-positive stromal cells were seen in 9 cases of MALT type and 22 cases of DLBL. Many dendritic cells (DC) expressed TP and formed an ill-defined meshwork in the background in 8 cases of MALT type and 17 cases of DLBL. In most cases, transition of CD68-positive stromal cells to DC expressing TP was recognized. There was more or less intermingling of CD3-positive T-cells in all cases. Expression of iNOS was seen in some stromal cells and glandular epithelial cells, but only in 3 cases of MALT type. In the germinal center (GC) colonization of MALT type there were CD21-positive follicular DC, CD68-positive stromal cells, TP-expressing DC and iNOS-expressing cells; whereas in that of DLBL the meshwork of CD21-positive follicular DC was destroyed and the stromal cells did not express TP or iNOS. Then, a peculiar co-existence of intermingling T-cells, CD68-positive stromal cells, DC expressing TP forming an ill-defined meshwork, and lymphoma cells were recognized in gBL. A small number of stromal cells and glandular epithelial cells expressed iNOS and prepared a nitric oxide-rich microenvironment for growth and transformation of MALT type lymphoma cells. This peculiar histogenesis of gBL was thought to explain a part of the mechanism of the anti-HP therapy against gBL.<br>

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