Genetic Analysis for JNK-mediated Apoptosis

  • Kuranaga Erina
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo
  • Miura Masayuki
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo

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Abstract

Recent genetic studies revealed crucial roles of JNK (c-jun N-terminal kinase) activation in cell death. However, the molecular mechanisms underlying JNK-mediated cell death are largely unknown. We present one of the JNK-mediated apoptotic mechanism is regulated by a ubiquitine-proteasome system.<br>

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