Immunohistochemical Localization of Laminin, Collagen Type IV and Heparan Sulfate Proteoglycan in Human Colorectal Adenocarcinoma: Correlation with Local Invasive Pattern and Lymph Node Metastasis.

• Kiyoshima Tamotsu

  Department of Oral Pathology, Faculty of Dentistry, Kyushu University

• Kobayashi Ieyoshi

  Department of Oral Pathology, Faculty of Dentistry, Kyushu University

• Matsuo Kou

  Department of Oral Pathology, Faculty of Dentistry, Kyushu University

• Ishibashi Yukiko

  Department of Oral Pathology, Faculty of Dentistry, Kyushu University

• Miyoshi Akira

  Department of Surgery, Chihaya Hospital

• Akashi Yoshio

  Department of Surgery, Chihaya Hospital

• Sakai Hidetaka

  Department of Oral Pathology, Faculty of Dentistry, Kyushu University

抄録

The extent of immunohistochemical localization of such basement membrane components (BMs) as laminin (LN), collagen type IV (C-IV) and heparan sulfate proteoglycan (HSPG) were investigated in 78 samples of human colorectal carcinoma, in correlation with histology of the invasive pattern at the parenchymal-stromal border of the invasive margin (PSB) and lymph node metastasis. The immunostaining ratio of BMs at the PSB was significantly lower in the type IV invasive pattern (PSB-IV) than in the other types, and was also significantly related to the incidence of lymphatic invasion and lymph node metastasis. A close relationship was also demonstrated between the PSB-IV and the prognosis of the patient or recurrence of the carcinoma, although there was no statistical significance. Furthermore, the immunostaining ratios of the IN and C-IV in the central areas (CAs) of the carcinoma tissue were also significantly lower in samples with lymph node metastasis than those without metastatic focus. These results thus indicate that the lower degree of immunostaining ratio of BMs at the PSB in human colorectal carcinomas is closely related to both the lymph node metastasis and the patient prognosis, while in addition the varied localization of BMs at the PSB affects diverse histopathological features in the invasive margin of carcinoma tissue. Moreover, the decreased immunostaining deposition of BMs in the CAs of carcinoma tissue also plays an important role in the pathway of lymph node metastasis. Therefore, further attention should be paid to the cellular biology of carcinoma cells localized in the CA, as well as those localized at the PSB, in order to disclose the metastatic cascade of colorectal carcinoma.

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 31 (1), 39-47, 1998

  日本組織細胞化学会

キーワード

• Human colorectal carcinoma
• Basement membrane components
• Invasive pattern
• Immunohistochemistry
• Lymph node metastasis and prognosis

詳細情報

• CRID: 1390001204861223552
• NII論文ID: 110003146806
• NII書誌ID: AA00508022
• DOI: 10.1267/ahc.31.39
• ISSN: 13475800
• ISSN: 00445991
• ISSN: http://id.crossref.org/issn/00445991
• Web Site: http://www.jstage.jst.go.jp/article/ahc1968/31/1/31_1_39/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10803051
• Web Site: https://search.jamas.or.jp/link/ui/1998187150
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可