Relationship between Nitric Oxide Synthase and Heme Oxygenase-2 in the Canine Esophagus.

DOI NDLデジタルコレクション Web Site 参考文献41件
  • Bamba Hitoshi
    Department of Otolaryngology, Kyoto Prefectural University of Medicine
  • Uno Toshiyuki
    Department of Otolaryngology, Kyoto Prefectural University of Medicine
  • Tamada Yoshitaka
    Department of Anatomy, Osaka Dental University
  • Tanaka Masaki
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
  • Ibata Yasuhiko
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
  • Hisa Yasuo
    Department of Otolaryngology, Kyoto Prefectural University of Medicine

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The relationship between neuronal nitric oxide synthase (n-NOS), and heme oxygenase-2 (HO-2), the enzyme synthesizing CO, in the myenteric plexuses of the canine esophagus were examined by means of double staining technique of NADPH-diaphorase (NADPH-d) histochemistry and HO-2 immunohistochemistry. The coexistent ratio was examined regarding three portions of the esophagus; the cervical, intrathoracic and subdiaphragmatic portions. In the myenteric neurons of all portions, n-NOS frequently coexisted with HO-2 but HO-2 only partially coexisted with n-NOS. Thus, NO cooperates with CO but CO has some functions independent of NO. Many NADPH-d reactive nerve fibers were detected but there were very few HO-2 immunoreactive nerve fibers around the blood vessels and exocrine glands in the esophagus. As a neurotransmitter, NO may be more important than CO because many NADPH-d reactive nerve fibers could be detected in the esophagus. Another possibility is that CO may act as a neuromodulator, rather than as a neurotransmitter.

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