Distribution of NADPH-Diaphorase-Positive Neurons in the Mouse Brain: Differences from Previous Findings in the Rat Brain and Comparison with the Distribution of Serotonergic Neurons.
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- Matsushita Hiroko
- Department of Pediatrics, Kyoto Prefectural University of Medicine
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- Takeuchi Yoshihiro
- Department of Pediatrics, Shiga University of Medical Science
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- Kawata Mitsuhiro
- Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine
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- Sawada Tadashi
- Department of Pediatrics, Kyoto Second Red Cross Hospital
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The distribution of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) enzyme-containing neurons in the mouse brain was studied and a schematic map of the entire mouse brain was obtained. NADPH-d-positive cell bodies and fibers were detected in almost all brain regions, while the neurons varied in form and staining pattern, and the fibers in density, shape and staining pattern. Significant differences in the localization of NADPH-d-positive neurons were detected and compared to the results of previous studies in rats, in such areas as the lateral globus pallidus, the red nucleus, the locus coeruleus and the principal sensory trigeminal nucleus. Possible causes for the differences between NADPH-d staining in rat and mouse are discussed. Similar to serotonin (5-hydroxytryptamine, 5-HT) fibers, as NADPH-d-positive neurons were found in almost all areas of the brain suggesting the existence of some interaction between NADPH-d-positive neurons and 5-HT neurons. Therefore, the distributions of NADPH-d-positive neurons and 5-HT neurons were compared. To elucidate the relationship between NADPH-d-positive neurons and 5-HT neurons, we analyzed histochemical changes in NADPH-d-positive neurons after injection of 5,7-dihydroxytryptamine (5,7-DHT), a 5-HT neurotoxin, into the lateral ventricle of the mouse brain. Changes in NADPH-d-positive neurons were found in the medial septal nucleus, the diagonal band of Broca, and the dorsal raphe nucleus after injection. The observations suggest a potential relationship between NADPH-d-positive neurons and 5-HT neurons.<br>
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 34 (4), 235-257, 2001
日本組織細胞化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679837342848
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- NII論文ID
- 110003150844
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- NII書誌ID
- AA00508022
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- COI
- 1:CAS:528:DC%2BD3MXotlCrsLk%3D
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可