MHC Class II Antigen Expression was Different from MHC Class I Antigen Expression in Irradiated and Recovering Rat Thymus.
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- Tokuda Nobuko
- Department of Anatomy, Yamaguchi University School of Medicine
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- Katsube Kousuke
- Department of Orthopedics, Yamaguchi University School of Medicine
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- Sakuragi Ayako
- Department of Anatomy, Yamaguchi University School of Medicine
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- Nagato Shinpei
- Department of Anatomy, Yamaguchi University School of Medicine
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- Harada Daisuke
- Department of Anatomy, Yamaguchi University School of Medicine
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- Arudchelvan Yamini
- Department of Oral and Maxillo-Facial Surgery, Yamaguchi University School of Medicine
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- Mizutani Noriko
- Department of Anatomy, Yamaguchi University School of Medicine
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- Wang Yu-Hsueh
- Department of Anatomy, Yamaguchi University School of Medicine
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- Sawada Tomoo
- Department of Anatomy, Yamaguchi University School of Medicine
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- Fujikura Yoshihisa
- Department of Anatomy, Oita Medical University School of Medicine
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- Fukumoto Tetsuo
- Department of Anatomy, Yamaguchi University School of Medicine
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抄録
We exposed rats to a heavy, but sublethal, dose of X-radiation that was calculated as the maximum that left them alive. Immediately after irradiation the rats lost body and thymus weight. The number of thymocytes decreased and the structure of the thymus was destroyed. The thymus weights then increased rapidly for a few days from day 7 followed by a slower increase. Immunohistochemically, the recovery of major histocompatibility complex (MHC) class II-positive cells in the thymus was slower than that of MHC class I-positive cells. Recovery of MHC Class II-positive and ED1-positive cells in the thymus was slow, especially in the medulla. Thymus structure appeared similar to normal control animals on day 14, although the number of MHC class II- and ED1-positive cells in the medulla was lower than that of controls even 21 days after radiation exposure. The delay in recovery of MHC class II-positive stromal cells might affect the regeneration of thymocyte subpopulations after irradiation.<br>
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 35 (2), 101-105, 2002
日本組織細胞化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679839778688
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- NII論文ID
- 110003150957
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- NII書誌ID
- AA00508022
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- COI
- 1:CAS:528:DC%2BD38Xlt1Crsbs%3D
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可