ラット口蓋ヒダの形成過程における抗ｃｙｔｏｋｅｒａｔｉｎ１８陽性細胞の分布に関する免疫組織化学的研究

DOI 被引用文献3件 参考文献39件

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  • Immunohistochemical studies on the distribution of anti-cytokeratin 18 immunoreactive cells during the development of rat palatine rugae.

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The appearance and distribution of anti-cytokeratin 18 (CK18) immunoreactive cells in rat palatine rugae during fetal and postnatal development were investigated by immunohistochemistry and transmission electron microscopy. At the 17-day embryonic stage, most cells in the top area of palatine rugae displayed a positive immunoreaction for anti-CK18 antibody. These cells rapidly decreased in number during prenatal and postnatal development and became clusters of CK18 immunoreactive cells of various sizes. The cluster of CK18 immunoreactive cells in the top area of palatine rugae remained at least until the 14th postnatal day. Electron microscopy revealed that the CK18 immunoreactive cells in the top area of palatine rugae possessed characteristics of taste-bud cells. On the other hand, CK18 immunoreactive, elliptical cells which were smaller than the former cells appeared de novo in the hillside epithelium of the palatine rugae at 4 days after birth. As these cells possessed a large number of dense cored granules 120 nm in diameter and digital like cytoplasmic projections, and, in addition, were in close contact to the nerve terminal, they were categorized as Merkel cells. These Merkel cells drastically increased in number until the 14th postnatal day. The present findings indicate that palatine rugae of the rat in the fetal and infant stages possess taste buds, and that Merkel cells in the rat palatine rugae begin differentiation postnatally.

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