Toward an Integrated Understanding of the Purkinje Fibers in the Heart: The Functional and Morphological Interconnection between the Purkinje Fibers and Ventricular Muscle

DOI NDLデジタルコレクション Web Site 被引用文献3件 参考文献45件
  • Tanaka Hideo
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
  • Hamamoto Tetsu
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
  • Takamatsu Tetsuro
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine

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Purkinje fibers are an essential element of the conduction system that provides for coordinated ventricular contraction of the heart. Although classic studies established structure and electrical activities of Purkinje fibers, an integrated understanding of the Purkinje-ventricular interconnection within the working heart remains to be had. In this review article we will briefly overview the gross anatomy and cytological characteristics of Purkinje fibers and their transition to the ventricular muscle, and we will discuss functional and morphological aspects of the Purkinje-ventricular interconnection from the perspectives of electrophysiology, distribution of gap junctions, and intracellular Ca2+ ([Ca2+] i) dynamics. Furthermore, the potential usefulness of the recently developed optical voltage-mapping and in situ real-time confocal [Ca2+]i imaging techniques is discussed as an integrated approach to the pathophysiological investigation of the Purkinje-ventricular interconnection in the heart.<br>

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