Effects of Late Administration of Immunoglobulin on Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

• Okabe Taka-aki

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kishimoto Chiharu

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

• Shimada Kana

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

• Murayama Toshinori

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

• Yokode Masayuki

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kita Toru

  Department of Cadiovascular Medicine, Graduate School of Medicine, Kyoto University

抄録

Background Although immunoglobulin treatment, beginning simultaneously with the initiation of atherosclerosis, suppresses experimental atherosclerosis in apolipoprotein E-deficient mice, it remains unclear whether the treatment at a subsequent stage of atherosclerosis would be effective. Methods and Results Experimental atherosclerosis was induced in mice fed a high-fat diet containing 0.3% cholesterol. After confirming the presence of atherosclerotic lesions at 11 weeks, the mice were treated with an intraperitoneal injection of either intact type of immunoglobulin or F(ab')₂ fragments of immunoglobulin (both, 1 g · kg ^-1 · day^-1) on alternate days over 4 weeks. Fatty streak lesion was suppressed by intact immunoglobulin administration, but not by F(ab')₂ fragments of immunoglobulin. Immunohistochemical analysis showed that macrophage and CD4⁺ T-cell accumulation in the fatty streak lesion was suppressed in mice that received intact immunoglobulin but not in those that received F(ab')₂ fragments. Conclusions Immunoglobulin treatment, even at a later stage of atherosclerosis, suppresses the development of lesions associated with the reduced expression of immune-activated cells in fatty streak plaques, demonstrating the benefits of immunoglobulin therapy for prevention of atherosclerosis. (Circ J 2005; 69: 1543 - 1546)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 69 (12), 1543-1546, 2005

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• F(ab') ₂ fragments
• Fc portion
• Immunoglobulin

詳細情報

• CRID: 1390282680080337408
• NII論文ID: 110003475381
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.69.1543
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/69/12/69_12_1543/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006248186
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可