Urinary Pharmacokinetics of Baicalein, Wogonin and Their Glycosides after Oral Administration of Scutellariae Radix in Humans.
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- Lai Miao-Ying
- Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College Department of Pharmacy, China Medical College
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- Hsiu Su-Lan
- Department of Pharmacy, China Medical College
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- Chen Chung-Chuan
- Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College
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- Hou Yu-Chi
- Department of Chinese Medicine, China Medical College
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- Chao Pei-Dawn Lee
- Department of Pharmacy, China Medical College
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抄録
Baicalin, baicalein, wogonoside and wogonin are flavone constituents of Scutellariae Radix with various beneficial biological activities. The purpose of this study was to investigate the urinary pharmacokinetics of these flavones after oral administration of Scutellariae Radix commercial powder. Ten healthy male volunteers received a dose of 5.2 g commercial powder (comparable to 9 g crude drug), respectively. The concentrations of baicalin, baicalein and wogonin in the commercial powder as well as their metabolites in urine were assayed by HPLC method. The glucuronides and sulfates of baicalein and wogonin in urine were hydrolyzed with β-glucuronidase and sulfatase, respectively. Our results showed that the mean cumulated renal excretion of baicalein glucuronides and sulfates were 43.1±4.5 μmol (2.9% of dose) and 64.8±6.3 μmol (4.3% of dose), respectively, whereas wogonin glucuronides and sulfates were 21.6±2.0 μmol (5.9% of dose) and 20.7±1.7 μmol (5.7% of dose), respectively. The result indicated that the renal excretion of conjugated metabolites of wogonin (11.6% of dose) were higher than that of baicalein (7.2% of dose). The baicalein sulfates was predominant than the corresponding glucuronides, whereas wogonin sulfates was comparable to the corresponding glucuronides.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 26 (1), 79-83, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602030976
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- NII論文ID
- 110003608294
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3sXjs1ejtbk%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6393774
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- PubMed
- 12520178
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可