Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice

• Yamada Jun

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Ujikawa Masanori

  Department of Pharmacology, Kobe Pharmaceutical University

抄録

We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. In this study, we studied the effects of insulin and adrenalectomy on hyperleptinemia induced by 5-HTP. Co-administration of insulin significantly increased hyperleptinemia elicited by 5-HTP. 5-HTP itself increased serum insulin levels. Adrenalectomy, which depletes corticosterone, did not abolish hyperleptinemic effects of 5-HTP. These results suggest that insulin may participate in hyperleptinemic effects of 5-HTP and that the involvement of corticosterone in effects of 5-HTP may be probably small.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 26 (10), 1491-1493, 2003

  公益社団法人 日本薬学会

キーワード

• leptin
• 5-hydroxytryptophan (5-HTP)
• 5-hydroxytryptamine (5-HT)
• insulin
• adrenalectomy
• corticosterone

詳細情報

• CRID: 1390282679604483968
• NII論文ID: 110003608331
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.26.1491
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6696719
• PubMed: 14519961
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6696719
• Web Site: http://www.jstage.jst.go.jp/article/bpb/26/10/26_10_1491/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004050824
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
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  • KAKEN
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