Functions of a Chitosan-Orotic Acid Salt in the Gastrointestinal Tract

• Murata Yoshifumi

  Faculty of Pharmaceutical Science, Hokuriku University

• Kojima Naoko

  Faculty of Pharmaceutical Science, Hokuriku University

• Kawashima Susumu

  Faculty of Pharmaceutical Science, Hokuriku University

抄録

A chitosan (CS)–orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2—2.7 μmol/mg CS-OT and this changed depending on the species of CS. CS-OT also adsorbed bile acids and the amount increased incrementally according to the number of amino group contained in CS. Furthermore, CS-OT was given to rats as feed in order to investigate the influence on serum cholesterol levels. A decrease in serum cholesterol levels was observed in the group, which was fed a diet containing CS-OT or CS for 1—2 weeks, but no differences in body weight changes were recognized. Therefore, CS-OT may be applied to treating hyperlipidemia.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 26 (5), 687-690, 2003

  公益社団法人 日本薬学会

キーワード

• chitosan
• orotic acid
• bile acid adsorption
• hyperlipidemia

詳細情報

• CRID: 1390001204625669248
• NII論文ID: 110003608498
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.26.687
• COI: 1:CAS:528:DC%2BD3sXltVeisrs%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6517288
• PubMed: 12736513
• Web Site: https://hokuriku.repo.nii.ac.jp/records/509
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6517288
• Web Site: http://www.jstage.jst.go.jp/article/bpb/26/5/26_5_687/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003297809
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可