Drug-Drug Interactions between Antiarrhythmic Drugs in Chick Embryos

• Yoshiyama Yuji

  Division of Clinical Pharmacy, Kyoritsu College of Pharmacy

• Sugiyama Takashi

  Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University

• Kanke Motoko

  Division of Clinical Pharmacy, Kyoritsu College of Pharmacy

• Tsuchimoto Kanji

  Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University

抄録

The drug–drug interactions between antiarrhythmic drugs were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Procainamide or flecainide with and without propranolol was injected into the air sac of a fertilized egg. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After each drug injection alone, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by combinations of procainamide and propranolol or flecainide and propranolol. In addition, arrhythmia was produced in combination with propranolol. These findings indicate that the drug–drug interactions between antiarrhythmic drugs have a marked influence on the heart rate in chick embryos.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 27 (1), 128-130, 2004

  公益社団法人 日本薬学会

キーワード

• drug–drug interaction
• procainamide
• flecainide
• propranolol
• chick embryo
• electrocardiogram

詳細情報

• CRID: 1390001204628170240
• NII論文ID: 110003608635
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.27.128
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6795732
• PubMed: 14709916
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6795732
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/1/27_1_128/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004169264
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可