Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense

• Abe Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Nagafuji Shinya

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Akahane Hiroshige

  Fukuoka University School of Medicine

• Estrada-Muñiz Elizabeth

  Institute of Chemistry, National University of Mexico

• Huerta-Reyes Maira

  Institute of Chemistry, National University of Mexico

• Reyes-Chilpa Ricardo

  Institute of Chemistry, National University of Mexico

Abstract

The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 27 (1), 141-143, 2004

  The Pharmaceutical Society of Japan

Keywords

• <i>Trypanosoma cruzi</i>
• <i>Garcinia intermedia</i>
• <i>Calophyllum brasiliense</i>
• trypanocidal activity
• Chagas' disease
• Guttiferae

Details

• CRID: 1390282679604873344
• NII Article ID: 110003608639
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.27.141
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 6795818
• PubMed: 14709920
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6795818
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/1/27_1_141/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004169267
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed